The game's first major expansion, Civilization VI: Rise and Fall, was released in February 2018. The game received generally positive reviews upon release, and it was awarded Best Strategy Game at The Game Awards 2016.

There is also new artificial intelligence mechanics for computer-controlled opponents, which includes secret goals and randomized engagements to disrupt an otherwise stable game. Other new features include research on the game's technology tree based on nearby terrain, a similar technology tree for cultural improvements and a better government civics structure for those playing on a cultural victory path. For example, a campus district must be built in order to house science-based buildings.

New to Civilization VI is the use of districts outside the city center to house most of the buildings. A critical design focus was to avoid having the player follow a pre-set path of improvements towards their civilization which they had observed from earlier games.

The game features several civilizations not featured in previous incarnations of Civilization, while many returning civilizations have new capitals or new leaders. Players do this by exploring the world, founding new cities, building city improvements, deploying military troops to attack and defend from others, researching new technologies and civics advancements, developing an influential culture, and engaging in trade and negotiations with other world leaders. Similar to previous installments, the goal for the player is to develop a civilization from an early settlement through many in-game millennia to become a world power and achieve one of several victory conditions, such as through military domination, technological superiority, or cultural influence, over the other human and computer-controlled opponents. The latest entry into the Civilization series, it was released on Microsoft Windows and macOS in October 2016, with later ports for Linux in February 2017, iOS in December 2017, Nintendo Switch in November 2018, PlayStation 4 and Xbox One in November 2019 and Android in 2020. The Mobile port was published by Aspyr Media. Sid Meier's Civilization VI is a turn-based strategy 4X video game developed by Firaxis Games, published by 2K Games, and distributed by Take-Two Interactive.

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